Margarida Espadinha Selected Research

Neoplasms (Cancer)

11/2022	Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors.
3/2021	Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma.
10/2018	Improving anticancer activity towards colon cancer cells with a new p53-activating agent.
1/2018	An Update on MDMX and Dual MDM2/X Inhibitors.
1/2017	DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.
1/2015	Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis.

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Margarida Espadinha Research Topics

Disease

6	Neoplasms (Cancer) 11/2022 - 01/2015
3	Colonic Neoplasms (Colon Cancer) 01/2021 - 01/2017
1	Triple Negative Breast Neoplasms 09/2023
1	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2023
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023
1	Adenocarcinoma 03/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Nervous System Diseases (Neurological Disorders) 05/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 09/2023 - 01/2018
3	LactamsIBA 03/2021 - 10/2018
2	tryptophanolIBA 03/2021 - 10/2018
2	Tumor Suppressor Protein p53IBA 03/2021 - 01/2018
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 05/2020 - 01/2017
1	AzidesIBA 09/2023
1	2-oxindole (oxindole)IBA 09/2023
1	Alkynes (Acetylenes)IBA 09/2023
1	CopperIBA 09/2023
1	spirooxindoleIBA 09/2023
1	EnzymesIBA 01/2023
1	Antineoplastic Agents (Antineoplastics)IBA 03/2021
1	Polycyclic CompoundsIBA 03/2021
1	OxindolesIBA 01/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2018
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	Memantine (Namenda)FDA Link 01/2017
1	DIMP53-1IBA 01/2017
1	AlkaloidsIBA 01/2015

Therapy/Procedure

3	Therapeutics 01/2023 - 01/2017
1	Drug Therapy (Chemotherapy) 10/2018